2020

​

Nisr, R.B., Shah, D.S. & Hundal, H.S. (2020) Mono- and Polyunsaturated Fatty Acids Counter Palmitate-Induced Mitochondrial Dysfunction in Rat Skeletal Muscle Cells.  Cell Physiol Biochem Oct 2020, 54:975-993. doi: 10.33594/000000282

​

Shah, D.S., Nisr, R.B., Stretton, C., Krasteva-Christ, G. & Hundal, H.S. (2020) Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function.  J Cachexia Sarcopenia Muscle 11: 838-858  doi: 10.1002/jcsm.12541.

​

2019

​

Nisr, R.B., Shah, D.S., Ganley, I.G. & Hundal, H.S. (2019) Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading.  Cell Mol Life Sci 76: 4887-4904. doi: 10.1007/s00018-019-03148-8 

​

Stretton, C., Lipina, C., Hyde, R., Cwikliniski, E., Hoffmann, T., Taylor, P.M. & Hundal, H.S. (2019) CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation https://doi.org/10.1016/j.bbamcr.2019.03.002

 

Lipina C, Walsh SK, Mitchell SE, Speakman JR, Wainwright CL, Hundal HS. (2018) GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues.  FASEB J.  doi: 10.1096/fj.201800171R. [Epub ahead of print]

​

2018

 

Lu, H, Bogdanovic, E., Yu, Z., Cho, C., Liu, L., Ho, K., Guo, J., Yeung, L.S.N., Lehmann, R., Hundal, H.S., Giacca, A., Fantus, I.G. (2018) Combined Hyperglycemia and Hyperinsulinemia-induced Insulin Resistance in Adipocytes is associated with Dual Signaling Defects mediated by PKC-ζ Endocrinology. 159:1658-1677. doi: 10.1210/en.2017-00312 

​

Hoffmann, T., Cwiklinski, E., Shah, D.S., Stretton,.C., Hyde, R., Taylor, P.M. & Hundal, H.S. (2018) Effects of sodium and amino acid substrate availability upon the expression and stability of the SNAT2 (SLC38A2) amino acid transporter. Frontiers in Pharmacology - Experimental Pharmacology and Drug Discovery 9:63. doi: 10.3389/fphar.2018.00063.

 

2017

​

Lipina C & Hundal HS (2017) Lipid modulation of skeletal muscle mass and function. Journal of Cachexia, Sarcopenia and Muscle 8:190-201 DOI:  10.1002/jcsm.12144

​

Lipina C & Hundal HS (2017) The endocannabinoid system: NO longer anonymous in the control of nitrergic signalling? J. Mol. Cell Biol.  9:91-103.  DOI: 10.1093/jmcb/mjx008

​

​

2016

​

Lipina C, Hundal HS (2016) Is REDD1 a Metabolic Éminence Grise? Trends Endocrinol Metab. 27: 868-880

 

Watson, A., Lipina, C., McArdle, H.J., Taylor, P.M., Hundal, H.S. (2016) Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1. Cellular Signalling, 28:412-424.

 

Lipina, C. & Hundal, H.S. (2016) Modulation of Cellular Redox Homeostasis by the Endocannabinoid System.  Open Biology 6:150276. doi: 10.1098/rsob.

 

Lipina, C., Vaanholt, L., Davidova, A., Mitchell, S., Storey-Gordon, E., Hambly, C., Irving, A.J., Speakman, J, Hundal, H.S. (2016) CB1 Receptor Blockade Counters Age-Induced Insulin Resistance and Metabolic Dysfunction. Aging Cell 15:325-35.

 

Tilston-Lünel, A.M., Haley, K.E., Schlecht, N.F., Wang, Y., Chatterton, A.L.D., Moleirinho, S., Watson, A., Hundal, H.S., Prystowsky, M.B., Gunn-Moore, F.J., & Reynolds, P.A. (2016) Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells. J. Mol. Cell Biol. doi: 10.1093/jmcb/mjw020

​

​

2015

​

Nardi, F., Hoffmann, T.M., Stretton, C., Cwiklinski, E., Taylor, P.M. & Hundal, H.S. (2015) Proteasomal Modulation of Cellular SNAT2 (SLC38A2) Abundance and Function by Unsaturated Fatty Acid Availability. J Biol. Chem. 290:8173-84.

 

Lipina, C., Nardi, F., Grace, H. & Hundal H.S. (2015) NEU3 Sialidase as a Marker of Insulin Sensitivity: Regulation by Fatty Acids. Cellular Signalling 27:1742-50.

 

Stretton, C., Hoffmann, T., Munson, M., Prescott, A.R., Ganley, I.G., Taylor, P.M. & Hundal, H.S. (2015) GSK3-mediated raptor phosphorylation supports amino acid-dependent mTORC1-directed signalling. Biochem. J. 470(2):207-21

 

Lipina, C., Hundal, H.S. (2015) Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms. FEBS Lett. 589:3221-3227.

​

 

2014

​

Lipina, C., Mitchell, M.H., Stretton, C & Hundal, H.S. (2014) The Role of Caveolin-Enriched Microdomains in the Regulation of Cellular Signalling and Energy Homeostasis.  In Lipid Rafts: Properties, Controversies and Roles in Signal Transduction (Ed D, Sillence) Nova Science Publishers, Inc.

 

Nardi F, Lipina C, Magill D, Hage Hassan R, Hajduch E, Gray A, Hundal H.S. (2014) Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A.  PLoS ONE. 9 (3):e92255

 

Lipina,C. Hundal, H.S. (2014) Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis.  Cellular Signalling 26: 2343-9.

 

Mahfouz, R., Khoury, R., Blachnio-Zabielska., A., Turban, S., Loiseau, N., Lipina, C., Stretton, C., Bourron, O., Ferre, P., Foufelle, F., Hundal, H.S., Hajduch, E. (2014) Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: A mechanistic insight. PLoS ONE. 9 (7): e101865

​

2013

Lipina C., Rastedt W., Irving A.J., and Hundal H.S. (2013) Endocannabinoids in obesity: brewing up the perfect metabolic storm? WIREs Membr. Transp. Signal. 2:49-63.

Lipina, C., Macrae, K., Suhmn T., Weigert, C., Blachnio-Zabielska., A. Baranowski, M., Gorski, J., Burgess, K., and Hundal H.S. (2013) Mitochondrial substrate availability and its role in lipid-induced insulin resistance and proinflammatory signalling in skeletal muscle. Diabetes 62:3426-36

Macrae K, Stretton C, Lipina C, Blachnio-Zabielska A, Baranowski M, Gorski J, Marley A, Hundal HS. (2013). Defining the role of DAG, mitochondrial function and lipid deposition in palmitate-induced proinflammatory signalling and its counter-modulation by palmitoleate. J. Lipid Res. 54:2366-78

 

Pre 2012

​

Turban, S., Stretton, C., Drouin, O., Green, C.J., Watson, M.L., Gray, A., Ross, F., Lantier, L., Viollet, B., Hardie, D.G., Marette, A. & Hundal, H.S. (2012) Defining the contribution of AMPK and PKCs in the regulation of glucose uptake by metformin in skeletal muscle cells. J. Biol. Chem. 287:20088-20099.

​

Lipina C., Rastedt W., Irving A.J., and Hundal H.S. (2012) New Vistas for Treatment of Obesity and Diabetes?  Endocannabinoid Signalling and Metabolism in the Modulation of Energy Balance.  BioEssays 34:681-91.

​

Watson, M., Macrae, K., Marley, A. & Hundal, H.S. (2011) Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells.  PLoS ONE 6(10): e25975.

Pinnila J., Aledo, J.C., Cwiklinski, E., Hyde, R. Taylor, P.M., & Hundal, H.S. (2011) SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation? Front. Biosci. (Elite Ed) 3: 1289-1299

Green, C.J., Macrae, K., Fogarty, S., Hardie, D.G., Sakamoto, K. & Hundal, H.S. (2011) Counter modulation of fatty acid-induced proinflammatory NFkB signalling in rat skeletal muscle cells by AMPK.  Biochem. J. 435: 463-474 

Lipina, C. & Hundal, H.S. (2011) Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance. Diabetologia 54: 1596-1607 

Lipina, C., Stretton, C., Hastings, S., Hundal, J.S., Mackie, K., Irving, A.J., Hundal, H.S. (2010) Regulation of MAP-kinase-directed mitogenic and PKB-mediated signalling by cannabinoid receptor type 1 in skeletal muscle cells. Diabetes, 59: 375-85

Lipina, C., Kendall, H., McPherron, A.C., Taylor , P.M., Hundal, H.S. (2010)  Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice. FEBS Lett. 584: 2403-2408

Stretton, C., Evans, A. Hundal, H.S. (2010)  Cellular depletion of atypical PKC lambda is associated with enhanced insulin-sensitivity and glucose uptake. Am. J. Physiol. 299: E402-412

Logie, L., Ruiz-Alcaraz, A.J., Schofield, C.J., Hundal, H.S., Feuerstein, G.Z., Brady, J.D., Crowther ,D., Tommasi, A.M., Grierson, C.E., Shepherd, B., Morris, A.D., Hansen, M.K., Pearson, E., Sutherland, C. (2010)  Generation, validation and humanisation of a novel insulin resistant cell model.  Biochem. Pharmacol. 80:1042-1049. 

Hundal, H.S. and Taylor, P.M. (2009) Amino acid transceptors: Gatekeepers of nutrient exchange and regulators of nutrient signaling.  Am. J.  Physiol.  297:E822-9.

Watson, M., Coghlan, M., Hundal, H.S. (2009) Modulating Serine Palmitoyl Transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells. Biochem. J. 417:791-801

Paytubi S, Wang X, Lam YW, Izquierdo L, Hunter MJ, Jan E, Hundal HS, Proud CG.  (2009) ABC50 promotes translation initiation in mammalian cells.  J. Biol. Chem. 284: 24061-73

Baird. F., Bett, K., Maclean, C., Tee, A.R., Hundal, H.S., Taylor, P.M. (2009) Tertiary active transport of amino acids reconstituted by co-expression of System A and L transporters in Xenopus oocytes.  Am. J. Physiol. (Endocrinol Metab) 297: E822-9

Stretton . C, Litherland, G.J., Moynihan, A., Hajduch. E., Hundal HS (2009) Expression and modulation of TUB by insulin and thyroid hormone in primary rat and murine 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 390:1328-33.  

Green, C.,  Göransson, O., Kular, G.,  Leslie, N.R.,  Gray, A.,  Alessi, D.R., Sakamoto, K.,  Hundal, H.S. (2008)  Use of Akti and a drug-resistant mutant validates a critical role for PKB/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake.  J. Biol. Chem.  283:27653-27667.

Hajduch, E., Turban, S., Le Liepvre, X., Le Lay, S., Lipina, C., Dimopoulos, N., Dugail, I., Hundal, H.S. (2008) Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signaling by ceramide. Biochem. J.  410: 369-379

Dimopoulos, N., Watson, M, Green, C., Hundal, H.S. (2007) The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells. FEBS Lett. 581:4743-4748.

Hyde, R., Cwiklinski, E.L., MacAulay, K., Taylor, P.M., Hundal, H.S. (2007) Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability. J Biol Chem. 282:19788-19798.

Liu, H.K., Perrier, S., Lipina, C., Finlay, D., McLauchlan, H., Hastie, C.J., Hundal, H.S., & Sutherland, C. (2006) Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226. BMC Mol Biol., 7:14.

Baird, F.E., Pinilla-Tenas, J.J., Ogilvie, W.L., Ganapathy, V., Hundal, H.S., & Taylor, P.M. (2006) Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue. Biochem. J., 397: 369-375

Dimopoulos, N. Watson, M., Sakamoto, K. & Hundal, H.S. (2006) Differenetial effects of palmitate and palmitoleate on insulin action and glucose utilisation in rat L6 skeletal muscle cells. Biochem. J., 399: 473-481.

Hyde,R.,  Hajduch, E.,  Powell, D.J., Taylor, P.M. & Hundal, H.S. (2005) Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells. FASEB J.  19: 461-463

MacAulay, K., Blair, A.S., Hajduch, E., Terashima, T., Baba, O., Sutherland, C., Hundal, H.S. (2005) Constitutive activation of GSK3 down regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells  J. Biol. Chem. 280: 9509-9518

Turban, S., Beardmore, V.A., Carr, J.M., Sakamoto, K., Arthur, J.S. & Hundal, H.S. (2005) Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle. Diabetes, 54:3161-8.

Ruiz-Alcaraz, A.J., Liu, H.K., Cuthbertson, D.J., McManus, E.J., Akhtar, S., Lipina, C., Morris, A.D., Petrie, J.R,, Hundal, H.S. & Sutherland, C. (2005) A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.  Biochem. J., 392:345-52 

Zhao, H., Hyde, R. & Hundal, H.S. (2004) Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells. J. Physiol. 2004 560:123-36. 

Powell, D, Turban, S., Gray, A., Hajduch, E. & Hundal, H.S. (2004) Intracellular ceramide synthesis and PKCζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem. J. 382: 619-629

Proud C.G., Hundal, H.S. & Taylor, P.M. (2004) Nutrient sensing in animal cells and integration of nutrient and endocrine signaling pathways. Topics in Current Genetics, Vol. 7 J. Winderickx, P.M. Taylor (Eds) Nutrient-Induced Responses in Eukaryotic Cells. Springer-Verlag Berlin Heidelberg

Litherland, G.J., Hajduch, E., Gould, G.W. & Hundal, H.S. (2004) Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance. Mol. Cell Biochem. 261: 23–33, 2004.

Powell, D., Hajduch, E., Kular, G. & Hundal, H.S. (2003) Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of PKB/Akt by a PKCz dependent mechanism. Mol. Cell. Biol. 2003 21:7794-808

Baird, F.E., Christie,G.R., Ganapathy, V., Hundal, H.S., Taylor. P.M. (2003) Inhibitory effects of glutamine antimetabolites on glutamine transporters. Nova Acta NF 87, NR. 329, 29-34.

MacAulay K, Hajduch E, Blair AS, Coghlan MP, Smith SA, Hundal HS. (2003) Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase. Eur. J. Biochem. 270(18):3829-38.

Hajduch E, Litherland GJ, Turban S, Brot-Laroche E, Hundal HS.  (2003) Insulin regulates the expression of the GLUT5 transporter in L6 skeletal muscle cells. FEBS Lett. 549(1-3):77-82.

Hyde R, Taylor PM, Hundal HS. (2003) Amino acid transporters: roles in amino acid sensing and signalling in animal cells. Biochem. J. 373(Pt 1):1-18. 

Hyde.R., Peyrollier.P., Hundal. H.S. (2002) Insulin promotes the cell surface recruitment of the SAT2/ATA2 system amino acid transporter from an endosomal compartment in skeletal muscle cells. J Biol Chem. 19;277(16):13628-34.

Christie. G.R., Hajduch. E., Hundal. H.S., Proud.C.G., Taylor.P.M. (2002) Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a TOR-dependent manner. J. Biol. Chem. 22;277(12):9952-7.

Ritchie.J.W., Baird.F.E., Christie.G.R., Stewart.A., Low.S.Y., Hundal.H.S., Taylor.P.M. (2001) Mechanisms of glutamine transport in rat adipocytes and acute regulation by cell swelling. Cell Physiol. Biochem. 11(5):259-70.

Litherland, G.J., Hajduch, E., Hundal, H.S. (2001) Intracellular signalling mechanisms regulating glucose transport in insulin sensitive tissues. Mol. Memb. Biol. 18(3):195-204. 

Hyde, R., Christie, G.R., Hundal, H.S. (2001) Regulation of amino acid transporters by amino acid availability. Curr. Opin. Clin. Nutr. Metab. Care.  4:425-431.

Hyde, R., Christie, G.R., Litherland, G.J., Hajduch, E., Taylor, P.M., Hundal, H.S., (2001) Subcellular localization and adaptive up-regulation of the System A (SAT2) amino acid transporter in skeletal-muscle cells and adipocytes. Biochem. J. 355:563-8.

Hajduch, E., Litherland, G.J. Hundal, H.S. (2001) Protein Kinase B (PKB/Akt): A key regulator of glucose transport?  FEBS Lett. 16;492(3):199-203. Mini Review.

Hajduch, E., Balendhran, A., Batty, I.H., Litherland, G.J., Blair, A.S.,Downes, C.P. & Hundal, H.S. (2001) Ceramide impairs the insulin-dependent membrane recruitment of Protein Kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia 44:173-183. 

Hajduch, E., Litherland, G.J. Hundal, H.S. (2000) Modulation of protein kinase B activity: consequences for insulin stimulated glucose transport. Hajduch. E, Litherland, G.J. Hundal, H.S.  Curr. Topics. Biochem. Res.  3:41-53.

Peyrollier, K., Hajduch, E., Gray, A., Litherland, G.J., Prescott, A.R., Leslie, N.R., & Hundal, H.S. (2000) A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B. Biochem. J. 352: 617-622.

​

Fryer, L.G.D, Hajduch, E., Rencurel, F., Salt, I.P., Hundal, H.S., Hardie, D.G. & Carling D. (2000) Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase. Diabetes 49(12):1978-85

Hajduch, E., Heyes, R.R., Watt, P.W. & Hundal, H.S. (2000) Lactate transport in rat adipocytes: identification of monocarboxylate transporter 1 (MCT1) and its modulation during streptozotocin-induced diabetes. FEBS Lett. 479: 89-92.

Peyrollier, K., Hajduch, E., Blair, A.S., Hyde, A.R. & Hundal, H.S. (2000) L-Leucine availability regulates PI3-kinase, p70 S6 Kinase and GSK-3 activity in L6 muscle cells: Evidence for the involvement of the mTOR pathway in the L-Leucine-induced upregulation of System A amino acid transport. Biochem. J. 350: 361-368.

Blair, A.S., Hajduch, E., Litherland, G.J. & Hundal, H.S. (1999) Regulation of Glucose Transport and Glycogen Synthesis in L6 Muscle Cells during Oxidative Stress: J. Biol. Chem. 274: 36293-36299.

Shah, S.W., Zhao, H., Low, S.Y., McArdle, H.J. & Hundal, H.S. (1999) Characterisation of glucose transport and glucose transporters in the human choriocarcinoma cell line, BeWo. Placenta, 20:651-659.

Hajduch, E., Rencurel, F., Balendran, A., Batty, I.H., Downes, C.P. and Hundal, H.S. (1999) Serotonin (5-Hydroxytryptamine), a Novel Regulator of Glucose Transport in Rat Skeletal Muscle. J. Biol. Chem. 274: 13563-13568.

​

Hajduch, E., Dombrowski, L., Darakhshan, F., Rencurel, F., Marette, A., Hundal, H.S. (1999) Biochemical localisation of the 5HT2A (Serotonin) receptor in rat skeletal muscle. Biochem. Biophys. Res. Comm. 257: 369-372.

​

McDowell, H.E., Eyers, P.A. and Hundal, H.S. (1998) Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress. FEBS Lett. 441, 15-19.

Richter, E.A., Kristiansen S., Wojtaszewski,J.F.P. , Hundal, H.S. (1998) Glucose transport and transporters in skeletal muscle. In : Biochemistry of Exercise (Eds. M. Hargreaves and M. Thompson), Champaign, Illinois, USA, 169-183.

Darakhshan, F., Hajduch, E., Kristiansen, S., Richter, E.A., & Hundal, H.S. (1998) Biochemical and functional characterisation of the GLUT5 fructose transporter in rat skeletal muscle. Biochem. J. 336, 361-366.

Hundal, H.S., Darakhshan,F., Blakemore, S.J., Kristiansen, S. and Richter, E. (1998) Fructose transport and GLUT5 expression in mammalian skeletal muscle. Adv. Exp. Med. Biol. 441: 35 - 45 

Hajduch, E., Alessi, D.R., Hemmings, B.A. & Hundal, H.S. (1998) Constitutive activation of Protein Kinase Ba by membrane targeting promotes glucose and System A amino acid transport, protein synthesis and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes 47: 1006 - 1013, 1998.

Hajduch, E., Darakhshan, F. & Hundal, H.S. (1998) Fructose uptake in rat adipocytes: GLUT5 expression and the effect of streptozotocin-induced diabetes. Diabetologia 41: 821-828. 

Kristiansen, S., Darakhshan, F., Richter, E. & Hundal, H.S. (1997) GLUT5 and fructose transport in human skeletal muscle. Am. J. Physiol. 273: E543-E548

Aledo, J.C., Lavoie, L., Volchuk, A., Keller, S.R., Klip, A. & Hundal, H.S. (1997) Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: Evidence for an endosomal and an insulin-sensitive GLUT4 compartment. Biochem. J. 325: 727-732.

McDowell, H.E., Walker, T., Hajduch, E., Christie, G., Batty, I.H., Downes, C.P. & Hundal, H.S. (1997) Inositol phospholipid 3-kinase is activated by cellular stress but is not required for the stress-induced activation of glucose transport in L6 rat skeletal muscle cells. Eur. J. Biochem. 247: 306-313.

Kemp, H.F., Hundal¸H.S. & Taylor, P.M. (1997) Glucose transport correlates with GLUT2 abundance in rat liver during altered Thyroid status. Mol. Cell. Endocrinol. 128: 97-102.

Hajduch, E., Aledo, J.C., Watts, C. & Hundal, H.S. (1997) Proteolytic cleavage of cellubrevin and VAMP (vesicle associated membrane protein) by tetanus toxin does not impair insulin stimulated glucose transport or GLUT4 translocation in rat adipocytes. Biochem. J. 321: 233-238.

Aledo, J.C., Hajduch, E., Darakhshan, F. & Hundal, H.S. (1996) Analyses of the co-localization of cellubrevin and the GLUT4 glucose transporter in rat and human insulin-responsive tissues FEBS Lett. 395: 211-216.

Blakemore, S.J., Rickhuss, P.K., Watt, P.W., Rennie, M.J. & Hundal, H.S. (1996) Effects of limb immobilization on muscle fibre characteristics, Cytochrome c-Oxidase activity, GLUT4 and GLUT5 protein expression in human skeletal muscle Clin. Sci. 91: 591-599.

Rennie, M.J., Khogali, S.E.O., Low, S.Y., McDowell, H.E., Hundal, H.S., Ahmed, A. & Taylor, P.M. (1996) Amino acid transport in heart and skeletal muscle and the functional consequences. Biochem. Soc. Trans. 24: 869 -873.

 
Rennie, M.J., Ahmed, A., Khogali, S.E.O., Low, S.Y., Hundal, H.S., & Taylor, P.M. (1996) Glutamine metabolism and transport in skeletal muscle and heart and their clinical relevance. Journal of Nutrition, 126: 1142S-1149S.

Hundal, H. S. & Aledo, J.C. (1996) Do subcellular fractionation studies of skeletal muscle yield useful information regarding sarcolemmal components? FEBS Lett. 384: 204-205.

Aledo, J.C.  Hundal, H.S. (1995) Sedimentation and immunological analyses of GLUT4 and the a2-Na,K-ATPase subunit-containing vesicles from rat skeletal muscle: Evidence for segregation. FEBS Lett. 376: 211-215.

McDowell, H.E., Christie, G.R., Stenhouse, G. & Hundal, H.S. (1995) Leucine activates System A amino acid transport in L6 rat skeletal muscle cells. Am. J. Physiol. 269: C1287-C1294.

Aledo, J.C., Darakhshan, F. & Hundal, H.S. (1995) Rab4, but not the transferrin receptor, is colocalized with GLUT4 in an insulin-sensitive intracellular compartment in rat skeletal muscle. Biochem. Biophys. Res. Comm. 215: 321-328.

Tsakiridis, T., McDowell, H.E., Walker, T., Downes, C.P., Hundal, H.S., Vranic, M. & Klip, A. (1995) Multiple roles of phosphatidyl inositol 3-kinase in the regulation of amino acid transport, glucose transport and glucose transporters in the rat L6 skeletal muscle cell line. Endocrinology 136: 4315-4322.

​

Hundal, H.S., Maxwell, D.L., Ahmed, A., Darakhshan, F., Mitsumoto, Y. & Klip, A. (1994) Subcellular distribution and immunocytochemical localization of Na,K-ATPase subunit isoforms in human skeletal muscle. Mol. Memb. Biol. 11: 255-262

​

Hundal, H.S. & Klip, A. (1993) Regulation of glucose transporters and Na/K ATPase isoforms by insulin in skeletal muscle.  Adv. Exp. Med. Biol. 334: 63 - 78.

 

Hundal, H.S., Marette, A., Ramlal, T., Liu, Z. & Klip, A. (1993)  Expression of ß subunit isoforms of the Na,K-ATPase is muscle type-specific.  FEBS Lett., 328: 253-258.

Bashan, N., Burdett, E., Hundal, H.S. & Klip, A. (1992) Regulation of glucose transport and Glut1 glucose transporter expression by oxygen levels in muscle cells. Am J. Physiol.  C682 C690.

​

Hundal, H.S., Marette, A., Mitsumoto, Y., Ramlal, T., Blostein, R. and Klip, A. (1992) Insulin induces translocation of the a2 and ß1 subunits of the Na/K ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle. J. Biol. Chem. 267: 5040 5043. (Communication)

​

Low, S.Y., Taylor, P.M., Hundal, H.S., Pogson, C.I. & Rennie, M.J. (1992) Transport of L glutamine and L glutamate across sinusoidal membranes of rat liver: effect of starvation, diabetes and corticosteroid treatment. Biochem. J.  284: 333 340.

Taylor, P.M., Macken~ie, B., Hundal, H.S., Robertson, E. & Rennie, M.J. (1992) Uptake and membrane binding of the glutamine analogue 6 Diazo 5 Oxo L Norleucine (DON) in Xenopus laevis oocytes. J. Memb. Biol.  128: 181-191.

 

Hundal, H.S., Ahmed, A., Guma, A., Mitsumoto, Y., Marette, A., Rennie, M.J. & Klip, A. (1992)  Biochemical and immunocytochemical localization of the "GLUT5 glucose transporter" in human skeletal muscle. Biochem. J. 286: 339 343. (Research Communication).
 

Hundal, H.S., Ramlal,T., Leiter, L. & Klip, A. (1992)  Cellular mechanism of Metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells Endocrinology, 131: 1165-1163.

Hundal, H.S., Taylor, P.M., Willhoft, N.M., Mackenzie, B., Low, S.Y., Ward, M.R. & Rennie M.J. (1992) A role for membrane transport in modulation of intramuscular glutamine turnover in the streptozotocin diabetic rat. Biochim. Biophys. Acta., 1180: 137-146

Hundal, H.S., Babij, P., Taylor, P.M., Watt, P.W. & Rennie, M.J.  Effects of corticosteroid on glutamine concentration, glutamine metabolic capacity and transport in rat hindlimb muscle. (1991) Biochim. Biophys. Acta. 1092: 376 383.

​

Hundal, H.S., Babij, P., Watt, P.W., Ward, M.R & Rennie, M.J. (1990) Glutamine transport and metabolism in denervated rat skeletal muscle.  Am. J. Physiol.  259: E148 E153.

Taylor, P.M., Hundal, H.S. & Rennie, M.J. (1989) The transport of glutamine in Xenopus laevis oocytes: relationship with transport of other amino acids.  J. Memb. Biol. 112, 149 157.

Hundal, H.S., Rennie, M.J. & Watt, P.W. (1989) Characteristics of acidic, neutral and basic amino acid transport in perfused rat skeletal muscle. J. Physiol. 408, 93 114.

​

Rennie, M.J., MacLennan, P.A., Hundal, H.S., Weryk, B., Smith, K., Taylor, P.M., Egan, C. & Watt, P.W. (1989) Skeletal muscle glutamine transport, intramuscular glutamine concentration and protein turnover. Metabolism 38: No.8  47 51.

Watt, P.W., MacLennan, P.A., Hundal, H.S., Kuret, C.M. & Rennie, M.J. (1988) L(+) Lactate transport in perfused rat skeletal muscle: kinetic characteristics and sensitivity to pH and transport inhibitors. Biochim. Biophys. Acta. 994, 213 222.

Hundal, H.S., Rennie, M.J. & Watt, P.W. (1987) Characteristics of L glutamine transport in perfused rat skeletal muscle. J. Physiol. 393, 283 305.

 

Rennie, M.J., Hundal, H.S., Babij, P., MacLennan, P.A., Taylor, P.M., Watt,P.W., Jepson, M.M. & Millward, D.J. (1986)  Characteristics of a glutamine carrier in skeletal muscle have important consequences for nitrogen loss in injury, infection and chronic disease. Lancet ii. 8514, 1008 1012.

​

​

​

FASEB J. 2018 Aug 27:fj201800171R. doi: 10.1096/fj.201800171R. [Epub ahead of print]